Can we live longer?

haiqu

Active member
Recent developments in biology suggest that the human body is capable of living to about 150 years old, according to a number of recent articles.


Having had an interest in such things since doing the MIT 7.00x Intro to Biology - The Secret of Life Course in 2019 as an extension of my genealogy hobby, I delved further. Apparently that ain't all, if you look into the work of expat Australian professor David Sinclair, PhD who works at Harvard University, and who has been named by Time as one of the 100 most influential people in the world and "the geneticist who is making age reversal real".

His discovery revolves around the NAD+ molecule, which while appearing pretty boring has a direct effect on aging. As we age, less of this is created by the body, leading to an exponential decay in health starting at around 40. By 60 years of age many people are already starting to drop off the twig, or suffer from chronic illnesses which can be directly ameliorated by having more NAD+ in the system. The theory goes that the human DNA is monitored by the microbiome, and that after correcting various breaks and errors over a lifetime the DNA becomes too messy to repair. This also leads to the interesting conclusion that one's DNA is only 20% responsible for our long term health, the rest being directly under our own control.

While Sinclair admits that the cheapest way to stay healthy is to intermittently fast, get regular exercise, sleep at least 7 hours a night and refrain from smoking and alcohol, he has also pointed out that Resveratrol (from red wine), Metformin (a cheap and plentiful drug used to treat type two diabetes), NMN (a supplement) and Berberine (an ancient Asian herb) have all been shown to help dramatically. Not that he can recommend taking these of course, since he isn't a medical doctor. (nudge, nudge, wink, wink)

But going a step further, experiments conducted by his team now show that aging can be reversed. In a test with mice, he restored the eyesight of animals which had had their optic nerve physically crushed; the result was regrowth of said nerve, all the way back to the brain.


Recommended reading
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Various YouTube videos in which he explains the mechanism being used in detail. He also has a book out: Lifespan - Why We Age, And Why We Don't Have To.

Here's one example:

Also worth looking up is the Horvath biological clock, a diagnostic method used to detect reversal of the test subject's biological age. It works by surveying methylation at selected loci and comparing to a standard set.

 
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Type4_PTS

Well-known member
While Sinclair admits that the cheapest way to stay healthy is to intermittently fast, get regular exercise, sleep at least 7 hours a night and refrain from smoking and alcohol, he has also pointed out that Resveratrol (from red wine), Metformin (a cheap and plentiful drug used to treat type two diabetes), NMN (a supplement) and Berberine (an ancient Asian herb) have all been shown to help dramatically. Not that he can recommend taking these of course, since he isn't a medical doctor. (nudge, nudge, wink, wink)
Metformin can have severe side effects. Whatever purpose it serves in reversing one's physiological age - there's got to be a better alternative.
 

guanoloco

As-Wased
Metformin can have severe side effects. Whatever purpose it serves in reversing one's physiological age - there's got to be a better alternative.
My guess is that it's along the lines of this:

 

haiqu

Active member
Metformin can have severe side effects. Whatever purpose it serves in reversing one's physiological age - there's got to be a better alternative.
The most common side effect of Metformin is nausea. Berberine is almost a 100% substitute, and requires no script.
 

haiqu

Active member

haiqu

Active member
Oh, I see. It's not a better alternative. Maybe your emeter has the answer?
That's right, The Game Changers is not a better alternative. Longevity has nothing to do with protein and strength.
 

guanoloco

As-Wased
The Game Changers has nothing to do with protein and strength.

It's all about vegan based instead of animal based.

It shows top performance competitive athletes that have made the switch and how their peak performance has markedly improved. That's it for strength and protein.
 

haiqu

Active member
My 1 kg package of powdered Berberine supplement arrived yesterday. Seven days from India to Australia is fantastic service. I took 1000 mg at lunchtime yesterday and noticed the following changes:

Immediate cure for chronic insomnia. I slept deeply for 12 hours last night and felt fantastic this morning.
Immediate disappearance of joint pain in knees, hips, wrists.
Immediate disappearance of "brain fuzz" and some improvement of eyesight.
Immediate reduction of constant runny nose and sore eyes.
Immediate reduction of swelling in throat tissue, eating feels different.
Immediate reduction of bowel issues.

I would have to say that if you're over 60 and not taking this stuff, you have rocks in your head. HIGHLY recommended.
 

Irayam

Well-known member
My 1 kg package of powdered Berberine supplement arrived yesterday. Seven days from India to Australia is fantastic service. I took 1000 mg at lunchtime yesterday and noticed the following changes:

Immediate cure for chronic insomnia. I slept deeply for 12 hours last night and felt fantastic this morning.
Immediate disappearance of joint pain in knees, hips, wrists.
Immediate disappearance of "brain fuzz" and some improvement of eyesight.
Immediate reduction of constant runny nose and sore eyes.
Immediate reduction of swelling in throat tissue, eating feels different.
Immediate reduction of bowel issues.

I would have to say that if you're over 60 and not taking this stuff, you have rocks in your head. HIGHLY recommended.
My God! And you still have 999 doses!
 

Irayam

Well-known member
My God! And you still have 999 doses!
It looks good. It is recommended to take it 3x daily because of the short half-life, for a total dosage of 500 to 1500 mg per day
 

haiqu

Active member
It looks good. It is recommended to take it 3x daily because of the short half-life, for a total dosage of 500 to 1500 mg per day
Yes, that's normally how it's taken. However I'm using Dr. David Sinclair's regimen and doing intermittent fasting as well. He recommends 1000 mg once a day.
 
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